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Syrup BetaGlucan Junior (with D vitamin)

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Honey-based syrup (142 g of honey in a single bottle) with patented Wellmune® beta-glucans and added vitamins and minerals. The syrup will ensure that the body is in constant readiness, reacts more quickly in case of an infection and is more resistant in the long-term. Excellent taste, suitable for children from 1 year up. 100% natural and preservatives-free.

Blagovna znamka: Medex
Intended use: Immunity , Energy
Product shape: syrup
Product packaging: bottle with 140 ml syrup
24,99 EUR
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Who is the BetaGlukan junior syrup intended for?

  • Children before starting kindergarten and school already from the age of 1 on.
  • Children with a weakened immune system.
  • Young athletes performing regular physical activities.
  • For the general well-being of all children, even in colder days of the year.
     
   

Is your child frequently sniffing?

Let the BetaGlukan junior syrup step in to help your immune system! The syrup contains patented Wellmune beta-glucans and carefully selected vitamins and minerals that provide additional support to the immune system of our youngest.

    

Does your child often miss kindergarten or school due to sickness?

We believe that this could be a major problem with children, for this reason we have developed a special product that represents an excellent support for your child's immune system. Help your youngest with long-term support of their immune system with the BetaGlukan junior syrup.
 
Our body detects beta-glucans as foreign molecules, this is why we stimulate our immune system by consuming products with beta-glucans.  Consequently, our immune system is in a state of constant readiness and reacts more quickly to eventual infections. Beta-glucans function according to the vaccine principle, and act as trainers of the immune system of children. At the same time, we added vitamins and minerals to the syrup, which were carefully adapted to the needs of children and which additionally assist in supporting your immune system.
  

Why choose the BetaGlukan junior syrup by Medex?

 
  • Because it contains patented Wellmune® beta-glucans, which are also the most researched.
  • Because vitamins C and D and zinc, which offer long-term support to the immune system of children, were added to it.
  • Because it does not contain preservatives due to carefully selected ingredients, making the syrup suitable for children from 1 year up.
  • Because it has an excellent taste. The syrup contains 74% of honey, pear juice and a natural raspberry aroma.
  • Because it contains oligofructose, which functions as a prebiotic.
  • Because it does not contain artificial colourings and aromas.


      

A syrup that contains 74% of honey

Did you know that the BetaGlukan junior syrup by Medex contains 74% of honey? A single bottle of the BetaGlukan junior syrup contains 142 grams of honey. The syrup is honey-based, since it significantly improves its taste and makes it more aromatic and more pleasant for consumption. At the same time, honey serves as a natural sweetener, the syrup therefore does not contain any added artificial sweeteners. In addition to this, the product protects against microorganisms, such as bacteria, fungi and yeast, thus acting as a natural preservative.

At the same time, honey is one of the active substances in the syrup. In addition to sugars, it contains substances that enable bees to preserve health, while having numerous benefits for humans. Bee enzymes, functional proteins and vegetable bioflavonoids belong to the most important substances it contains. It also contains various antioxidants and some types of honey also have probiotic and prebiotic properties.


       
   
   



 

What are beta-glucans?


Beta-glucans are natural molecules consisting of long and branched chains of interconnected glucose units. They are found in fungi, bacteria and algae, and are also present in cereals.

Already in the 1950s, scientists have discovered for the first time that consuming beta-glucans affects the immune system. They later found that not all beta-glucans are equally effective in this regard, but this mainly depends on their branching. The most effective are those that contain mostly 1.3 and 1.6 glycosidic bonds as in beta-glucans found in fungi. On the other hand, beta-glucans from cereals, which contain mostly 1.3 and 1.4 glycosidic bonds, do not have this effect.

In order to be effective, it is also important that beta-glucans are well purified and do not contain residues of lipids and other sugars.


   
   

Why do we need to train our immune system?

The immune response in humans is roughly divided into congenital (non-specific response) and acquired (specific response with antibodies) immune response. Until recently, the existence of immune memory has been considered as merely an acquired immune response, when as a reaction to an infection specific antibodies develop, making us resistant in case of future infections with the same virus/bacteria.

In the last 10 years, however, more and more discoveries have been made about the development of the memory of congenital immune response. The latter develops when the body first encounters viruses and bacteria or their structural parts, resulting in the immune system being “trained” and in the establishment of a state of higher readiness that may last from a few weeks to several months.

A congenital immune system “trained” in such a way responds more quickly and effectively to possible new challenges. Since we have specialized immune cells also in the intestine, we can train the immune system also through the consumption of certain substances that by their composition are similar to pathogen microorganisms, such as beta-glucans from yeast cell walls.

   

How do Wellmune® beta-glucans work in training the immune system?

 

The human body recognizes beta-glucans as foreign molecules (they are naturally present in algae, fungi and bacteria walls), which stimulates the immune system. Specialized cells in the epithelium of the digestive tract bind beta-glucans and present them to cells of the immune system. This activates the cells of the congenital immune system, resulting in a constant readiness of the immune system. Cells activated in this manner react faster to eventual viral infections according to the vaccine principle. In a certain way, beta-glucans function as trainers of our immune system.

Wellmune® is one of the most researched beta-glucans, supported by numerous clinical studies. It contains highly purified beta-(1.3/1.6)-D-glucans and is obtained from yeast cell walls (Saccharomyces cerevisiae) through an advanced technological procedure.


       

How do vitamins added to the syrup function?

  • Vitamin C, vitamin D and zinc have a role in the function of the immune system.
  • Vitamin C contributes to the reduction of tiredness and fatigue.
  • Zinc contributes to normal cognitive functions.


The syrup contains a natural source of vitamin C

Its scientific name Malpighia glabra classifies it into the family Malpighiaceae. The bright red fruit is edible and has 2-3 seeds in its core. It is juicy, has a sweet and sour taste and contains a great amount of vitamin C, approximately 20-times more than a lemon.

A single fruit has approximately 1,500 mg of vitamin C per 100 g of fresh weight. With maturing, the quantity of vitamin C decreases; however, this is also a process in which the fruit acquires flavonoids that have antioxidant properties.

In recent times, acerola is increasingly becoming a sought-after raw material due to its effects.  It was added to the BetaGlukan junior syrup, since we wanted to ensure that our youngest get vitamin C from a natural source.
   

    

What is the role of vitamin D in the organism?

Vitamin D contributes to normal functioning of the immune system of children. The BetaGlukan junior syrup contains vitamin D in its natural D3 form (cholecalciferol), which absorbs well into the body. Experts have discovered that vitamin D-binding receptors are located in the cells of various tissues all over the body, and can also be found in most of the cells of the immune system.

By binding to certain DNA sequences, vitamin D regulates the expression of genes that are important for the normal function of the immune system. This is exactly why optimal quantities of vitamin D in the blood are extremely important for the normal function of the immune system.

Our body is able to produce vitamin D itself, under natural sunlight, mainly in the warmest part of the year. However, despite this most Slovenian do not achieve a sufficient level of vitamin D during summer months, and in the colder part of the year this figure increases to 80%. That is why it is important that vitamin D is added also in the form of a food supplement when there is a vitamin D deficiency in blood.
      
    
     

What is the role of zinc?

The mineral zinc is important for the function of the immune system and metabolism. According to research results, zinc is also necessary for DNA formation and cell division, and at the same time it also supports normal growth and development during pregnancy, childhood and youth. Zinc functions as a co-factor in numerous enzyme reactions which are necessary for a normal excretion of cytokines and chemokines and for the activation, differentiation and reproduction of cells of the immune system, mainly T-lymphocytes.  At the same time, it functions as an antioxidant that alleviates oxidative stress upon inflammation.
     

      

Why is zinc bioavailability important?

The bioavailability of active substances is important due to absorption. Usually, the term bioavailability refers to the quantity of a reabsorbed active substance which is actually available in the target tissue. Bioavailability is therefore one of the main pharmacokinetic characteristics of active substances. Zinc bioavailability means how well it absorbs into the body. Zinc, which was added to the BetaGlukan junior syrup, comes in the form of organic salt (zinc gluconate), which has the best bioavailability or absorption in the digestive tract.
    

Literature:

Aaby P, Roth A, Ravn H, Napirna BM, Rodrigues A, Lisse IM, Stensballe L, Diness BR, Lausch KR, Lund N, Biering-Sørensen S, Whittle H, Benn CS. Randomized trial of BCG vaccination at birth to low-birth-weight children: beneficial nonspecific effects in the neonatal period? J Infect Dis. 2011 Jul 15;204(2):245-52. doi: 10.1093/infdis/jir240. PMID: 21673035.
 
Domínguez-Andrés J, Joosten LA, Netea MG. Induction of innate immune memory: the role of cellular metabolism. Curr Opin Immunol. 2019 Feb;56:10-16. doi: 10.1016/j.coi.2018.09.001. Epub 2018 Sep 19. PMID: 30240964.
 
Moorlag SJCFM, Khan N, Novakovic B, Kaufmann E, Jansen T, van Crevel R, Divangahi M, Netea MG. β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1. Cell Rep. 2020 May 19;31(7):107634. doi: 10.1016/j.celrep.2020.107634. PMID: 32433977; PMCID: PMC7242907.
 
de Laval B, Maurizio J, Kandalla PK, Brisou G, Simonnet L, Huber C, Gimenez G, Matcovitch-Natan O, Reinhardt S, David E, Mildner A, Leutz A, Nadel B, Bordi C, Amit I, Sarrazin S, Sieweke MH. C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells. Cell Stem Cell. 2020 May 7;26(5):657-674.e8. doi: 10.1016/j.stem.2020.01.017. Epub 2020 Mar 12. Erratum in: Cell Stem Cell. 2020 May 7;26(5):793. PMID: 32169166
 
Rice PJ, Adams EL, Ozment-Skelton T, Gonzalez AJ, Goldman MP, Lockhart BE, Barker LA, Breuel KF, Deponti WK, Kalbfleisch JH, Ensley HE, Brown GD, Gordon S, Williams DL. Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge. J Pharmacol Exp Ther. 2005 Sep;314(3):1079-86. doi: 10.1124/jpet.105.085415. Epub 2005 Jun 23. PMID: 15976018.
 
Geller A, Yan J. Could the Induction of Trained Immunity by β-Glucan Serve as a Defense Against COVID-19? Front Immunol. 2020 Jul 14;11:1782. doi: 10.3389/fimmu.2020.01782. PMID: 32760409; PMCID: PMC7372085.
 
de Graaff P, Govers C, Wichers HJ, Debets R. Consumption of β-glucans to spice up T cell treatment of tumors: a review. Expert Opin Biol Ther. 2018 Oct;18(10):1023-1040. doi: 10.1080/14712598.2018.1523392. PMID: 30221551.
 
Talbott, S. and Talbott, J. (2010). "Beta 1,3/1,6 glucan decreases upper respiratory tract infection symptoms and improves psychological wellbeing in moderate to highly-stressed subjects." AgroFood industry hi-tech 21(1): 21-24.
 
McFarlin, BK, Carpenter, KC, Davidson T, McFarlin MA  2013. Baker’s Yeast Beta Glucan supplementation increase salivary IgA and decreases cold/flu symptomatic days after intense exercise.  J. Dietary Supplements. 10:171-183.
 
Meng F (2016) Baker’s Yeast Beta-Glucan Decreases Episodes of Common Childhood Illness In 1 to 4 Year Old Children during Cold Season in China. J Nutr Food Sci 6: 518. doi:10.4172/2155-9600.1000519

Maggini, S, Pierre, A, Calder, PC (2018). Immune function and micronutrient requirements change over the life course. Nutrients  (10), 1531

Simmer K, Thompson RP. Zinc in the fetus and newborn. Acta Paediatr Scand Suppl. 1985;319:158-63. 
   


Proizvajalec: Medex d.o.o., Slovenija
 
The recommended daily intake:
Children between 1 and 3 years of age: 0.5 of the enclosed spoon once per day (2.5 ml)
Children between 4 and 9 years of age: 1 enclosed spoon once per day (5 ml)
Children between 10 and 14 years of age: 2 enclosed spoons once per day (10 ml)

Recommended consumption:
Use the enclosed spoon to help you measure the recommended daily dose.
The syrup is intended for children from the age of 1 year old. We recommend that you consume the syrup on an empty stomach. The best option is to take it in the morning, at least half an hour before a meal, or in the evening, before going to bed. In order to boost the immune system, we recommend a long-term consumption of at least 30 days. You can take the product continuously, for a longer period of time. In the event of an increased need, you can double the dose.

Warning:
  • If you are undergoing immunosuppresant therapy, you can only take the product upon prior consultation with your doctor.
  • Use is not recommended for persons allergic to any of the ingredients.
  • The recommended daily dose should not be exceeded.
  • The dietary supplement is no substitute for a balanced and varied diet. It is important to adhere to the guidelines for a healthy lifestyle.
  • Keep out of reach of children!
  • Store in a dark and dry place at the temperature of up to 25°C.
  • Use up to 3 months after you open the bottle.
Ingredients: honey, water, concentrated pear juice, oligofructose, powdered acerola juice (Malpighia glabra, maltodextrine) – natural source of vitamin C, beta-glucans from powdered baker’s yeast – Wellmune®, vitamin C (calcium L-ascorbate), zinc gluconate, vitamin D, antioxidant: alpha tocopherol, natural aromas, acid: citric acid.
 
Content 2,5 ml (NRV*) 5 ml (NRV**) 10 ml (NRV***) 10 ml (NRV****)
Beta-glucans
Wellmune®
35 mg 70 mg 140 mg 140 mg
Vitamin C 12 mg (60 %) 24 mg (64 %) 48 mg (64 %) 48 mg (60 %)
Vitamin D 5 μg (25 %) 10 μg (50 %) 20 μg (100 %) 20 μg (400 %)
Zinc 1 mg (33 %) 2 mg (33 %) 4 mg (48 %) 4 mg (40 %)
Honey 2,5 g 5 g 10 g 10 g
*Recommended daily dose in % for children between 1 and 3 years of age (source: reference values of the National Institute of Public Health).
** Recommended daily dose in % for children between 4 and 9 years of age (source: reference values of the National Institute of Public Health).
*** Recommended daily dose in % for children between 10 and 14 years of age (source: reference values of the National Institute of Public Health).
**** Nutrient reference value in % for adults.

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